Opportunity Information: Apply for PAR 22 092
The National Institutes of Health (NIH) funding opportunity PAR-22-092, titled "Health Care Models for Persons with Multiple Chronic Conditions from Populations that Experience Health Disparities: Advancing Health Care towards Health Equity (R01 - Clinical Trials Optional)," supports research aimed at improving how health care is delivered to people who live with multiple chronic conditions (MCCs) and who also come from populations that experience health disparities. The core emphasis is not just on studying individual diseases in isolation, but on testing practical ways health systems can better adapt, integrate, and implement evidence-based clinical guidelines when patients have several chronic illnesses at the same time and face structural, social, or economic barriers to high-quality care. The larger purpose is to move health care toward measurable health equity by improving treatment quality, care experiences, and health outcomes for groups that have historically been underserved or disproportionately burdened.
This initiative is looking for innovative, collaborative, and multidisciplinary projects, meaning proposals are expected to bring together perspectives and methods from multiple fields such as clinical medicine, nursing, public health, behavioral science, implementation science, health services research, informatics, community engagement, and policy. The work is centered on understanding what it actually takes to make recommended care happen in real-world settings for complex patients, including how guidelines can be adapted without losing clinical integrity, how services can be coordinated across conditions, and how implementation can be sustained over time. Importantly, NIH signals that strong applications will likely go beyond a single intervention lever, instead addressing more than one component of care delivery and/or more than one level of influence. In practice, that could include combining patient-level supports (like education, self-management tools, culturally tailored coaching, or navigation) with clinician-level strategies (like decision support, training, or workflow redesign) and system-level changes (like care coordination infrastructure, team-based care models, integrated behavioral health, quality improvement systems, or payment and referral arrangements).
The target population is people with MCCs who are part of populations that experience health disparities, which often includes groups affected by factors like racism and discrimination, poverty, geographic isolation, limited access to specialty care, language barriers, disability, and under-resourced health systems. Projects are expected to engage these realities directly and show how the proposed health care model, or modifications to an existing model, will reduce inequities rather than inadvertently widen them. The program language underscores outcomes that matter for equity: better alignment of care with recommended guidelines across multiple conditions, improved clinical outcomes, improved patient-centered outcomes (such as functioning and quality of life), and improved health system outcomes (such as access, continuity, coordination, safety, and appropriate utilization). While the opportunity does not require a clinical trial, it allows clinical trials when they are an appropriate method for evaluating the intervention or model, which gives applicants flexibility to propose either experimental designs or other rigorous implementation and health services research approaches.
The funding mechanism is an NIH R01 research project grant, and the opportunity is categorized under discretionary grant funding with activity areas spanning education and health. Multiple CFDA listings are associated with this announcement (93.173, 93.279, 93.307, 93.313, 93.361, 93.393, 93.846, 93.866, 93.867), reflecting the cross-institute relevance of chronic disease, aging, minority health, and health services improvement. The opportunity was created on January 10, 2022, and the original closing date listed is September 7, 2024. The notice does not specify an award ceiling or the expected number of awards in the provided source information, so applicants typically would need to consult the full NIH announcement for budget limits, project period expectations, and review considerations.
Eligibility is broad and includes a wide range of U.S.-based organizations that can carry out health research and implementation work. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education when specified); for-profit organizations other than small businesses; small businesses; and other eligible entities. The announcement also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, tribal governments other than federally recognized ones, and U.S. territories or possessions. At the same time, it places clear limits on foreign involvement: non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined in the NIH Grants Policy Statement) are not allowed.
Overall, this opportunity is designed for teams that can demonstrate a credible path from evidence to practice for complex, high-need patients, with explicit attention to the real-world barriers that drive disparities. Competitive projects would typically be expected to show strong partnerships with health care delivery settings and, when appropriate, community organizations; a clear plan for adapting guideline-based care to patients with multiple conditions; attention to multilevel implementation challenges; and outcomes that meaningfully indicate progress toward equitable health care and equitable health results.Apply for PAR 22 092
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Health Care Models for Persons with Multiple Chronic Conditions from Populations that Experience Health Disparities: Advancing Health Care towards Health Equity (R01 - Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173, 93.279, 93.307, 93.313, 93.361, 93.393, 93.846, 93.866, 93.867.
- This funding opportunity was created on 2022-01-10.
- Applicants must submit their applications by 2024-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the NIH funding opportunity PAR-22-092?
PAR-22-092 is a National Institutes of Health (NIH) funding opportunity titled "Health Care Models for Persons with Multiple Chronic Conditions from Populations that Experience Health Disparities: Advancing Health Care towards Health Equity (R01 - Clinical Trials Optional)." It supports research projects that test and evaluate practical health care models (or improvements to existing models) for people living with multiple chronic conditions (MCCs) who are also from populations that experience health disparities.
What is the main goal of this opportunity?
The goal is to move health care toward measurable health equity by improving how care is delivered to complex patients with multiple chronic conditions, especially when structural, social, and economic barriers reduce access to high-quality care. The emphasis is on real-world changes that improve care quality, care experiences, and health outcomes for historically underserved or disproportionately burdened groups.
What does NIH mean by "health care models" in this announcement?
In the context of this opportunity, "health care models" refers to how care is organized and delivered across patients, clinicians, and systems. This includes approaches that help health systems adapt, integrate, and implement evidence-based clinical guidelines when patients have several chronic illnesses at the same time, and when care must be delivered in settings facing resource constraints or inequity-driven barriers.
Is the focus on specific diseases or on care delivery across conditions?
The core emphasis is not on studying individual diseases in isolation. Instead, projects should focus on improving care delivery across multiple chronic conditions, including how evidence-based guidelines are implemented and coordinated when patients have more than one condition.
Who is the target population for the proposed research?
The target population is people with multiple chronic conditions (MCCs) who are part of populations that experience health disparities. The announcement describes realities often connected to disparities, such as racism and discrimination, poverty, geographic isolation, limited access to specialty care, language barriers, disability, and under-resourced health systems.
What kinds of health disparities are relevant to this opportunity?
This opportunity is aimed at populations affected by structural, social, or economic barriers to care. Examples mentioned include barriers related to racism and discrimination, poverty, geographic isolation, limited specialty access, language barriers, disability, and under-resourced health systems.
What types of outcomes does NIH want applicants to improve?
The opportunity highlights outcomes that matter for equity, including: better alignment of care with recommended guidelines across multiple conditions; improved clinical outcomes; improved patient-centered outcomes (such as functioning and quality of life); and improved health system outcomes (such as access, continuity, coordination, safety, and appropriate utilization).
What does "advancing health equity" mean in this program?
Within this opportunity, advancing health equity means designing and testing care models that reduce inequities rather than inadvertently widening them, and demonstrating improvement in equity-relevant outcomes like guideline-concordant care, patient-centered outcomes, and system performance for populations that experience health disparities.
Are clinical trials required under PAR-22-092?
No. Clinical trials are not required. The opportunity is labeled "Clinical Trials Optional," meaning applicants can propose a clinical trial when it is an appropriate method to evaluate the intervention or model, but they can also propose other rigorous implementation and health services research approaches.
What kinds of research approaches or study designs fit this opportunity?
Based on the information provided, NIH is looking for rigorous research that evaluates how evidence-based care is implemented in real-world settings for complex patients. This can include experimental approaches such as clinical trials (when appropriate) or other implementation and health services research approaches that can credibly assess whether the model improves equity-relevant outcomes.
What does NIH mean by "multidisciplinary" and "collaborative" projects?
Applications are expected to bring together perspectives and methods from multiple fields. The announcement lists examples such as clinical medicine, nursing, public health, behavioral science, implementation science, health services research, informatics, community engagement, and policy.
Does NIH expect projects to address more than one part of the care delivery system?
Yes. The announcement signals that strong applications will likely go beyond a single intervention lever and instead address more than one component of care delivery and/or more than one level of influence (for example, combining patient-level, clinician-level, and system-level strategies).
What are examples of patient-level strategies mentioned in the announcement?
Examples include education, self-management tools, culturally tailored coaching, and patient navigation supports.
What are examples of clinician-level strategies mentioned in the announcement?
Examples include clinical decision support, training, and workflow redesign.
What are examples of system-level strategies mentioned in the announcement?
Examples include care coordination infrastructure, team-based care models, integrated behavioral health, quality improvement systems, and payment and referral arrangements.
What is the funding mechanism for PAR-22-092?
The funding mechanism is an NIH R01 research project grant.
What type of funding opportunity is this categorized as?
It is categorized under discretionary grant funding, with activity areas spanning education and health.
Which CFDA listings are associated with this opportunity?
The opportunity lists multiple CFDA numbers: 93.173, 93.279, 93.307, 93.313, 93.361, 93.393, 93.846, 93.866, and 93.867. These reflect cross-institute relevance to chronic disease, aging, minority health, and health services improvement.
When was this funding opportunity created?
The opportunity was created on January 10, 2022.
What is the closing date listed in the provided information?
The original closing date listed is September 7, 2024.
Does the provided information state an award ceiling or the expected number of awards?
No. The provided information does not specify an award ceiling or the expected number of awards. Applicants would typically need to consult the full NIH announcement for budget limits, project period expectations, and review considerations.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organizations capable of carrying out health research and implementation work. Examples listed include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education when specified); for-profit organizations other than small businesses; small businesses; and other eligible entities.
Are minority-serving institutions specifically highlighted as eligible?
Yes. The announcement highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible to apply?
Yes. Faith-based or community-based organizations are listed among eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed as eligible.
Are foreign organizations or non-U.S. entities eligible to apply?
No. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply under this opportunity.
Can a U.S. organization include a non-domestic component in the project?
No. Non-domestic components of U.S. organizations are not eligible.
Are foreign components allowed in any form?
No. Foreign components (as defined in the NIH Grants Policy Statement) are not allowed.
What kinds of partnerships are likely to strengthen an application?
Based on the opportunity description, competitive projects would typically be expected to show strong partnerships with health care delivery settings and, when appropriate, community organizations.
What does NIH mean by adapting evidence-based clinical guidelines for people with multiple chronic conditions?
The announcement emphasizes the practical challenge of making recommended care happen in real-world settings for patients with multiple conditions. This includes adapting guideline-based care across conditions without losing clinical integrity, coordinating services across multiple needs, and sustaining implementation over time.
How does the opportunity address sustainability of implementation?
Sustainability is explicitly referenced as an important consideration. The announcement notes the need to understand what it takes not only to implement recommended care, but also to sustain it over time in real-world settings.
What could make a project less aligned with the stated emphasis of this opportunity?
Based on the information provided, projects that focus only on a single disease in isolation, or that do not directly address real-world implementation barriers and equity concerns for populations experiencing health disparities, would be less aligned with the described focus on integrated care models and measurable progress toward health equity.
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Applicants who have applied for this opportunity (PAR 22 092) also looked into and applied for these:
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| Accelerating the Pace of Drug Abuse Research Using Existing Data (R21 Clinical Trial Optional) Apply for RFA DA 22 038 Funding Number: RFA DA 22 038 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Optional) Apply for PAR 22 091 Funding Number: PAR 22 091 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Not Allowed) Apply for PAR 22 090 Funding Number: PAR 22 090 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Epidemiologic Research on Emerging Risk Factors and Liver Cancer Susceptibility (R21 Clinical Trial Not Allowed) Apply for PAR 22 084 Funding Number: PAR 22 084 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Emergency Awards: HEAL Initiative-Early-Stage Discovery of New Pain and Opioid Use Disorder Targets Within the Understudied Druggable Proteome (R21 Clinical Trial Not Allowed) Apply for RFA TR 22 011 Funding Number: RFA TR 22 011 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Stimulating Access to Research in Residency (StARR) (R38) Apply for RFA HL 23 006 Funding Number: RFA HL 23 006 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Epidemiologic Research on Emerging Risk Factors and Liver Cancer Susceptibility (R01 Clinical Trial Not Allowed) Apply for PAR 22 083 Funding Number: PAR 22 083 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Cancer Tissue Engineering Collaborative: Enabling Biomimetic Tissue-Engineered Technologies for Cancer Research (R01 Clinical Trial Optional) Apply for PAR 22 099 Funding Number: PAR 22 099 Agency: National Institutes of Health Category: Education, Health Funding Amount: $40,000 |
| Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed) Apply for PAR 22 058 Funding Number: PAR 22 058 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Evaluating the Impact of COVID-19 Pandemic-related Food and Housing Policies and Programs on Health Outcomes in Health Disparity Populations (R01 Clinical Trial Optional) Apply for RFA NR 22 001 Funding Number: RFA NR 22 001 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Integrating Mental Health Care into Health Care Systems in Low- and Middle-Income Countries (R01 Clinical Trial Optional) Apply for RFA MH 22 130 Funding Number: RFA MH 22 130 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Limited Competition: NIH Neuroscience Doctoral Readiness Program (DR. Program) (R25 Clinical Trial Not Allowed) Apply for RFA NS 22 035 Funding Number: RFA NS 22 035 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Data, Evaluation and Coordinating Center for: A Multilevel Approach to Connecting Underrepresented Populations to Clinical Trials (CUSP2CT) (U24 Clinical Trial Not Allowed) Apply for RFA CA 22 014 Funding Number: RFA CA 22 014 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Investigating Transposable Elements and Mobile DNA as Targets of Integration for Establishing HIV Reservoirs in the Brain (R61/R33 - Clinical Trial Optional) Apply for RFA DA 23 003 Funding Number: RFA DA 23 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Microbial-based Cancer Imaging and Therapy - Bugs as Drugs (R21 Clinical Trial Not Allowed) Apply for PAR 22 086 Funding Number: PAR 22 086 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Microbial-based Cancer Imaging and Therapy - Bugs as Drugs (R01 Clinical Trial Not Allowed) Apply for PAR 22 085 Funding Number: PAR 22 085 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Administrative Supplements to Support Cancer Disparity Collaborative Research (Clinical Trial Optional) Apply for PAR 22 114 Funding Number: PAR 22 114 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Implementing Comprehensive HIV services in Syringe Service Program (SSP) Settings (R34 - Clinical Trial Required) Apply for RFA DA 23 007 Funding Number: RFA DA 23 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Implementing Comprehensive HIV services in Syringe Service Program (SSP) Settings (R01 - Clinical Trial Required) Apply for RFA DA 23 006 Funding Number: RFA DA 23 006 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Cancer Control Research in Persistent Poverty Areas (U54 Clinical Trial Optional) Apply for RFA CA 22 015 Funding Number: RFA CA 22 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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